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Journal: bioRxiv
Article Title: Lacticaseibacillus rhamnosus GR-1 attenuates Escherichia coli -induced endometritis in mice, accompanied by modulation of uterine microbiota and metabolite profiles
doi: 10.64898/2026.02.09.704851
Figure Lengend Snippet: (A) Mouse experimental design. Four groups were set up: From day 0 to day 2, except for the CONT group, the uteri of mice in the other groups were infused with E.coli at a concentration of 1.0×10⁸ CFU/mL. From day 3 to day 6, the CONT group and ECOL group were given PBS; the GR-1 group was given L. rhamnosus GR-1 (1.0×10⁹ CFU/mL, 100 μL); the AMP group was given ampicillin (0.1 mg/100 μL). On day 7, some mice were sacrificed. From day 7 to day 12, the “mating and breeding period” was conducted. Group abbreviations: CONT (control group), ECOL ( E.coli group), GR-1 ( L. rhamnosus group), AMP (ampicillin group),. (B) Changes in body temperature, n=6. (C) Changes in mouse body weight, n=6. (D) Analysis of histological scores. (E) Histomorphology of the uterus, n=3. (F) Uterine tissue bacterial, n=6. Data represented are mean ± SD, *p<0.05; **p<0.01; ***p<0.001.
Article Snippet:
Techniques: Concentration Assay, Control
Journal: bioRxiv
Article Title: Lacticaseibacillus rhamnosus GR-1 attenuates Escherichia coli -induced endometritis in mice, accompanied by modulation of uterine microbiota and metabolite profiles
doi: 10.64898/2026.02.09.704851
Figure Lengend Snippet: (A) Venn diagram of overlapping and group-specific differential metabolites. (B) Distribution of all metabolites. Distribution of differential metabolites: (C) ECOL group vs. AMP group and (E) ECOL group vs. GR-1 group. Expression levels of different differential metabolites: (D) ECOL group vs. AMP group and (F) ECOL group vs. GR-1 group. KEGG functional annotation and enrichment analysis of differential metabolites: (G) ECOL group vs. AMP group and (H) ECOL group vs. GR-1 group, n=6.
Article Snippet:
Techniques: Expressing, Functional Assay
Journal: bioRxiv
Article Title: Lacticaseibacillus rhamnosus GR-1 attenuates Escherichia coli -induced endometritis in mice, accompanied by modulation of uterine microbiota and metabolite profiles
doi: 10.64898/2026.02.09.704851
Figure Lengend Snippet: (A) The Spearman analysis (heatmap) was used to analyze the correlation between differential metabolites and differential microorganisms between the ECOL group and the GR-1 group. (B) Spearman analysis (heat map) was performed to analyze the correlation between inflammatory markers, oxidative indicators, and changes in uterine microbiota. The color scale of the heat map indicates the Pearson correlation coefficients. In (A), darker blue and yellow represent higher absolute values, while in (B), darker red and blue indicate higher absolute values. *p<0.05; **p<0.01; ***p <0.001, n=6.
Article Snippet:
Techniques: